Motor signs in the prodromal phase of Parkinson's disease.
Identifieur interne : 000D08 ( Main/Exploration ); précédent : 000D07; suivant : 000D09Motor signs in the prodromal phase of Parkinson's disease.
Auteurs : Walter Maetzler [Allemagne] ; Jeffrey M. HausdorffSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- MESH :
- diagnosis : Parkinson Disease.
- genetics : Parkinson Disease.
- physiopathology : Parkinson Disease.
- Early Diagnosis, Humans, Risk.
Abstract
Relatively subtle deterioration of the motor system likely occurs well before the patient meets established motor criteria for a clinical diagnosis of Parkinson's disease; ie, the occurrence of at least 2 of the cardinal motor deficits: bradykinesia, rigidity, tremor, and/or postural instability. Powerful compensatory mechanisms may mask these clinical symptoms and make them difficult to identify and evaluate in the earliest stages of the illness. This review summarizes our current knowledge of motor signs that are thought to occur in the prodromal phase of Parkinson's disease and suggests how motor assessment batteries could be designed to detect these subclinical motor deficits with a high degree of accuracy and sensitivity.
DOI: 10.1002/mds.24973
PubMed: 22437964
Affiliations:
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Le document en format XML
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Hausdorff</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24973</idno><idno type="RBID">pubmed:22437964</idno><idno type="pmid">22437964</idno><idno type="wicri:Area/PubMed/Corpus">000E26</idno><idno type="wicri:Area/PubMed/Curation">000E26</idno><idno type="wicri:Area/PubMed/Checkpoint">000D36</idno><idno type="wicri:Area/Ncbi/Merge">003604</idno><idno type="wicri:Area/Ncbi/Curation">003604</idno><idno type="wicri:Area/Ncbi/Checkpoint">003604</idno><idno type="wicri:Area/Main/Merge">000D28</idno><idno type="wicri:Area/Main/Curation">000D08</idno><idno type="wicri:Area/Main/Exploration">000D08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Motor signs in the prodromal phase of Parkinson's disease.</title><author><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name><affiliation wicri:level="3"><nlm:affiliation>Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. walter.maetzler@uni-tuebingen.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center of Neurology, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M" last="Hausdorff">Jeffrey M. Hausdorff</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Early Diagnosis</term><term>Humans</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (physiopathology)</term><term>Risk</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Early Diagnosis</term><term>Humans</term><term>Risk</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Relatively subtle deterioration of the motor system likely occurs well before the patient meets established motor criteria for a clinical diagnosis of Parkinson's disease; ie, the occurrence of at least 2 of the cardinal motor deficits: bradykinesia, rigidity, tremor, and/or postural instability. Powerful compensatory mechanisms may mask these clinical symptoms and make them difficult to identify and evaluate in the earliest stages of the illness. This review summarizes our current knowledge of motor signs that are thought to occur in the prodromal phase of Parkinson's disease and suggests how motor assessment batteries could be designed to detect these subclinical motor deficits with a high degree of accuracy and sensitivity.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Tübingen</li></region><settlement><li>Tübingen</li></settlement></list><tree><noCountry><name sortKey="Hausdorff, Jeffrey M" sort="Hausdorff, Jeffrey M" uniqKey="Hausdorff J" first="Jeffrey M" last="Hausdorff">Jeffrey M. Hausdorff</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Maetzler, Walter" sort="Maetzler, Walter" uniqKey="Maetzler W" first="Walter" last="Maetzler">Walter Maetzler</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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